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|a 9781441956354
|9 978-1-4419-5635-4
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|a 10.1007/978-1-4419-5635-4
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|a Inflammation and Retinal Disease: Complement Biology and Pathology
|h [electronic resource] /
|c edited by John D. Lambris, Anthony P. Adamis.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2010.
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|a XIV, 170 p.
|b online resource.
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|a text
|b txt
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 703
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| 505 |
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|a The Case for Complement and Inflammation in AMD: Open Questions -- The Role of Complement in AMD -- Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report -- Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration -- Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration -- The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma -- A Role for Complement in Glaucoma? -- The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease -- Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration -- A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration -- Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-Related Macular Degeneration.
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| 520 |
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|a Numerous studies have pointed to the key role of complement in the pathogenesis of retinal disease, particularly age-related macular degeneration (AMD). Reports about new gene associations and links to other physiological pathways are emerging almost on a weekly base. Several promising clinical candidates covering a wide area of potential treatment applications are in the pipelines of both industrial and academic groups. This indicates an increasing interest in complement as a therapeutic target. In view of these exciting discoveries, scientists from around the world convened at the 1st Aegean Conferences Conference on Inflammation and Retinal Disease: Complement Biology and Pathology (June 10-17, 2007) in Crete, Greece, to discuss recent advances in this rapidly-evolving field. This volume represents a collection of topics on the functions of complement in eye diseases, pathophysiology, protein structures, and complement therapeutics discussed during the conference.
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| 650 |
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|a Medicine.
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| 650 |
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|a Ophthalmology.
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|a Medicine & Public Health.
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|a Ophthalmology.
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| 700 |
1 |
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|a Lambris, John D.
|e editor.
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| 700 |
1 |
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|a Adamis, Anthony P.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9781441956347
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 703
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-1-4419-5635-4
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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