Polyploidization and Cancer
Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence...
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| Format: | Electronic eBook |
| Language: | English |
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New York, NY :
Springer New York,
2010.
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| Series: | Advances in Experimental Medicine and Biology,
676 |
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| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- Polyploidy, Aneuploidy and the Evolution of Cancer
- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability
- Understanding Cytokinesis Failure
- DNA Damage and Polyploidization
- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization
- Centrosomes, Polyploidy and Cancer
- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells
- Polyploidization of liver cells
- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.
