Proteins Membrane Binding and Pore Formation

Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid mem...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Anderluh, Gregor (Editor), Lakey, Jeremy (Editor)
Format: Electronic eBook
Language:English
Published: New York, NY : Springer New York, 2010.
Series:Advances in Experimental Medicine and Biology, 677
Subjects:
Online Access:Full Text via HEAL-Link
Table of Contents:
  • Energetics of Peptide and Protein Binding to Lipid Membranes
  • Membrane Association and Pore Formation by Alpha-Helical Peptides
  • Role of Membrane Lipids for the Activity of Pore Forming Peptides and Proteins
  • Cholesterol-Dependent Cytolysins
  • Laetiporus sulphureus Lectin and Aerolysin Protein Family
  • Interfacial Interactions of Pore-Forming Colicins
  • Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins
  • Molecular Mechanism of Sphingomyelin-Specific Membrane Binding and Pore Formation by Actinoporins
  • Hemolysin E (HlyE, ClyA, SheA) and Related Toxins
  • Pore formation by Cry toxins
  • Role of Heparan Sulfates and Glycosphingolipids in the Pore Formation of Basic Polypeptides of Cobra Cardiotoxin
  • Amyloid Peptide Pores and the Beta Sheet Conformation.