Insect Nicotinic Acetylcholine Receptors

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Thany, Steeve Hervé (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York, 2010.
• Σειρά: Advances in Experimental Medicine and Biology, 683
• Θέματα: Medicine.; Biomedicine.; Biomedicine general.

 The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles. 

 Identification of Cholinergic Synaptic Transmission in the Insect Nervous System -- The Evolution of Pentameric Ligand-Gated Ion Channels -- Diversity of Insect Nicotinic Acetylcholine Receptor Subunits -- Identification of Critical Elements Determining Toxins and Insecticide Affinity, Ligand Binding Domains and Channel Properties -- Electrophysiological Studies and Pharmacological Properties of Insect Native Nicotinic Acetylcholine Receptors -- Characterisation of Insect Nicotinic Acetylcholine Receptors by Heterologous Expression -- Neonicotinoid Insecticides -- Ecotoxicity of Neonicotinoid Insecticides to Bees -- State of the Art on Insect Nicotinic Acetylcholine Receptor Function in Learning and Memory.