The Tumor Microenvironment

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Bagley, Rebecca G. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2010.
• Σειρά: Cancer Drug Discovery and Development
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

The field of cancer biology and developmental therapeutics is continually evolving as new methodologies are developed and new targets are discovered. Although multiple therapeutics directly target the malignant cells these drugs rarely prevent recurrence of disease or the progression of metastasis....

Πίνακας περιεχομένων:

• Physiological Parameters
• Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy
• The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases
• Hypoxia, Gene Expression, and Metastasis
• Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX
• Glycolytic Pathway as a Target for Tumor Inhibition
• Malignant Cells
• Aberrant DNA Methylation in Cancer Cells
• DNA Repair and Redox Signaling
• Cancer Stem Cells and Microenvironment
• Epithelial–Mesenchymal Transition in Development and Diseases
• Invasion and Metastasis
• Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment
• Vasculature And Stroma
• Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing Controversy
• Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth
• Integrin Signaling in Lymphangiogenesis
• Role of Pericytes in Resistance to Antiangiogenic Therapy
• Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas
• Immune-Mediated Cells
• Mast Cells and Tumor Microenvironment
• Macrophages in the Tumor Microenvironment
• The Prognostic Significance of Tumor-Infiltrating Lymphocytes
• The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation
• Natural Killer Cells for Adoptive Immunotherapy
• Extracellular Matrix
• Fibronectin
• Collagen in Cancer
• Integrins and Cancer
• Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis
• Tetraspanins and Cancer Metastasis
• Secreted Proteins
• Chemokines and Metastasis
• Transforming Growth Factor-? in Lung Cancer, Carcinogenesis, and Metastasis
• Cooperative Interactions Between Integrins and Growth Factor Signaling in Pathological Angiogenesis
• The Extracellular Matrix and the Growth and Survival of Tumors
• Secreted Growth Factors as Therapeutic Targets
• Adrenomedullin.