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03606nam a22004815i 4500 |
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978-1-4419-6676-6 |
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DE-He213 |
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20151204164900.0 |
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110110s2010 xxu| s |||| 0|eng d |
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|a 9781441966766
|9 978-1-4419-6676-6
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|a 10.1007/978-1-4419-6676-6
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|a Conjugation and Deconjugation of Ubiquitin Family Modifiers
|h [electronic resource] :
|b Subcellular Biochemistry /
|c edited by Marcus Groettrup.
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|a New York, NY :
|b Springer New York,
|c 2010.
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|a XX, 252 p. 58 illus., 16 illus. in color.
|b online resource.
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|a text
|b txt
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|a Subcellular Biochemistry,
|x 0306-0225 ;
|v 54
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|a Activation of Ubiquitin and Ubiquitin-Like Proteins -- Control of Ubiquitin Conjugation by Cdc48 and Its Cofactors -- Regulation of Ubiquitin Receptors by Coupled Monoubiquitination -- Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8 -- Control of Deneddylation by the COP9 Signalosome -- Mechanism, Specificity and Structure of the Deubiquitinases -- Ubiquitin Conjugation and Deconjugation in NF-?B Signaling -- Functions of Linear Ubiquitin Chains in the NF-?B Pathway -- Assembly of K11-Linked Ubiquitin Chains by the Anaphase-Promoting Complex -- Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53 -- Ubiquitylation in the ERAD Pathway -- Pupylation -- Sumo Control -- The In Vivo Functions of Desumoylating Enzymes -- Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways -- Sumoylation as a Signal for Polyubiquitylation and Proteasomal Degradation -- In Vivo Functions of Isgylation -- Identification and Validation of ISG15 Target Proteins -- FAT10.
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|a † 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18.
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|a Life sciences.
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|a Human physiology.
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|a Molecular biology.
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|a Proteins.
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|a Life Sciences.
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|a Protein Science.
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|a Human Physiology.
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|a Molecular Medicine.
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|a Groettrup, Marcus.
|e editor.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9781441966759
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|a Subcellular Biochemistry,
|x 0306-0225 ;
|v 54
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|u http://dx.doi.org/10.1007/978-1-4419-6676-6
|z Full Text via HEAL-Link
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|a ZDB-2-SBL
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|a Biomedical and Life Sciences (Springer-11642)
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