BetaSys Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Booß-Bavnbek, Bernhelm (Editor), Klösgen, Beate (Editor), Larsen, Jesper (Editor), Pociot, Flemming (Editor), Renström, Erik (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Edition: 1.
• Series: Systems Biology ; 2
• Subjects: Life sciences.; Human genetics.; Diabetes.; Bioinformatics.; Systems biology.; Life Sciences.; Systems Biology.; Human Genetics.
• Physical Description: XX, 556 p. online resource.
• ISBN: 9781441969569

The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.