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|a 9781441969569
|9 978-1-4419-6956-9
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|a 10.1007/978-1-4419-6956-9
|2 doi
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|a 570
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|a BetaSys
|h [electronic resource] :
|b Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells /
|c edited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
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|a 1.
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|a New York, NY :
|b Springer New York,
|c 2011.
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| 300 |
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|a XX, 556 p.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
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|a text file
|b PDF
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|a Systems Biology ;
|v 2
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|a Preface -- Systems biology of β-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in β-cells -- β-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic β-cells -- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in β-cell function -- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the β-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in β-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index.
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| 520 |
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|a The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.
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| 650 |
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|a Life sciences.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Diabetes.
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| 650 |
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|a Bioinformatics.
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| 650 |
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|a Systems biology.
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4 |
|a Life Sciences.
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| 650 |
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|a Systems Biology.
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| 650 |
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|a Human Genetics.
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| 650 |
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4 |
|a Bioinformatics.
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| 650 |
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4 |
|a Diabetes.
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| 700 |
1 |
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|a Booß-Bavnbek, Bernhelm.
|e editor.
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| 700 |
1 |
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|a Klösgen, Beate.
|e editor.
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| 700 |
1 |
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|a Larsen, Jesper.
|e editor.
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| 700 |
1 |
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|a Pociot, Flemming.
|e editor.
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| 700 |
1 |
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|a Renström, Erik.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
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8 |
|i Printed edition:
|z 9781441969552
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| 830 |
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|a Systems Biology ;
|v 2
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-1-4419-6956-9
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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