BetaSys Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Booß-Bavnbek, Bernhelm (Editor), Klösgen, Beate (Editor), Larsen, Jesper (Editor), Pociot, Flemming (Editor), Renström, Erik (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Edition: 1.
• Series: Systems Biology ; 2
• Subjects: Life sciences.; Human genetics.; Diabetes.; Bioinformatics.; Systems biology.; Life Sciences.; Systems Biology.; Human Genetics.

The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological adva...

Table of Contents:

• Preface
• Systems biology of β-cells - revisited
• Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach
• Mitochondria and metabolic signals in β-cells
• β-cell ontogenesis and the insulin production apparatus
• The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells
• The mathematical microscope making the inaccessible accessible
• Magnetic resonance imaging of pancreatic β-cells
• Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches
• In vivo applications of inorganic nanoparticles
• Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts
• Bioimpedance spectroscopy
• DNA variations, impaired insulin secretion and type-2 diabetes
• Genetically programmed defects in β-cell function
• Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities
• Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes
• Present state of islet transplantation for type-1 diabetes patients
• Predictive protein networks and identification of drugable targets in the β-cell
• Nanotoxicity
• From silicon cell to silicon human
• Probing cellular dynamics with mesoscopic simulations
• What drives calcium oscillations in β-cells? new tasks for cyclic analysis
• Whole-body and cellular models of glucose-stimulated insulin secretion
• Geometric and electromagnetic aspects of fusion pore making
• Index.