Protein Metabolism and Homeostasis in Aging

Aging is loosely defined as the accumulation of changes in an organism over time. At the cellular level such changes are distinct and multidimensional: DNA replication ceases, cells stop dividing, they become senescent and eventually die. DNA metabolism and chromosomal maintenance, together with pro...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Other Authors: Tavernarakis, Nektarios (Editor)
Format: Electronic eBook
Language:English
Published: Boston, MA : Springer US, 2010.
Series:Advances in Experimental Medicine and Biology, 694
Subjects:
Online Access:Full Text via HEAL-Link
Table of Contents:
  • Synthesis, Modification and Turnover of Proteins during Aging
  • Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control
  • Protein Synthesis and the Antagonistic Pleiotropy Hypothesis of Aging
  • Proteasome Function Determines Cellular Homeostasis and the Rate of Aging
  • Autophagy and Longevity: Lessons from C. elegans
  • Autophagy and Aging: Lessons from Progeria Models
  • Regulation of Protein Turnover by Longevity Pathways
  • Protein Metabolism and Lifespan in Caenorhabditis elegans
  • Mitochondrial Protein Quality Control Systems in Aging and Disease
  • p38MAPK in the Senescence of Human and Murine Fibroblasts
  • Protein Homeostasis in Models of Aging and Age-Related Conformational Disease
  • Roles for SUMO Modification during Senescence
  • Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging
  • Sensory Influence on Homeostasis and Lifespan: Molecules and Circuits
  • Regulation of Muscle Atrophy in Aging and Disease
  • Confronting Cellular Heterogeneity in Studies of Protein Metabolism and Homeostasis in Aging Research.