Obesity Before Birth Maternal and prenatal influences on the offspring /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Lustig, Robert H. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US : Imprint: Springer, 2011.
• Σειρά: Endocrine Updates, 30
• Θέματα: Medicine.; Human genetics.; Food > Biotechnology.; Endocrinology.; Medicine & Public Health.; Human Genetics.; Food Science.

Obesity obeys the First Law of Thermodynamics. The routine assumption is that obesity is the result of a mismatch between calories in and calories out; in other words, the result of two divergent behaviors. However, there is mounting evidence that biochemical forces can drive obligate weight gain, a...

Πίνακας περιεχομένων:

• Preface
• Obesity: nature or nurture?
• The contribution of heredity to clinical obesity
• Monogenetic disorders within the energy balance pathway
• Ciliary syndromes and obesity
• Genome-wide association studies and human population obesity
• Known clinical epigenetic disorders with an obesity phenotype: Prader-Willi Syndrome and the GNAS locus
• Evidence for epigenetic changes as a cause of clinical obesity
• Epigenetic changes associated with intrauterine growth retardation and adipogenesis
• Exposure to diabetes in utero, offspring growth, and risk for obesity
• Maternal weight gain during pregnancy and obesity in the offspring
• Intrauterine growth restriction, small for gestational age, and experimental obesity
• Experimental models of maternal obesity and high-fat diet during pregnancy and programmed obesity in the offspring
• High carbohydrate intake only during the suckling period results in adult-onset obesity in mother as well as offspring
• Prenatal stress, glucocorticoids, and the metabolic syndrome
• Hypothalamic maldevelopment and developmental programming
• Adipocyte development and experimental obesity
• The obesogen hypothesis of obesity: overview and human evidence
• Perinatal exposure to endocrine disrupting chemicals with estrogenic activity and the development of obesity
• The role of environmental obesogens in the obesity epidemic.