BeadChip Molecular Immunohematology Toward Routine Donor and Patient Antigen Profiling by DNA Analysis /

We have entered the era of molecular immunohematology in which DNA is analyzed to predict red blood cell and platelet phenotypes. Indeed, many laboratories and blood banks across the world have already adopted and implemented molecular techniques. Some fear that serology is now becoming outdated, bu...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Ness, Paul M. (Επιμελητής έκδοσης), Sloan, Steve R. (Επιμελητής έκδοσης), Moulds, JoAnn M. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York, 2011.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 04421nam a22005415i 4500
001 978-1-4419-7512-6
003 DE-He213
005 20151125211917.0
007 cr nn 008mamaa
008 101125s2011 xxu| s |||| 0|eng d
020 |a 9781441975126  |9 978-1-4419-7512-6 
024 7 |a 10.1007/978-1-4419-7512-6  |2 doi 
040 |d GrThAP 
050 4 |a R-RZ 
072 7 |a MBGR  |2 bicssc 
072 7 |a MED000000  |2 bisacsh 
082 0 4 |a 610  |2 23 
245 1 0 |a BeadChip Molecular Immunohematology  |h [electronic resource] :  |b Toward Routine Donor and Patient Antigen Profiling by DNA Analysis /  |c edited by Paul M. Ness, Steve R. Sloan, JoAnn M. Moulds. 
264 1 |a New York, NY :  |b Springer New York,  |c 2011. 
300 |a XXII, 152 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a An overview of the Classical Serological methods: limitations and benefits of serology and DNA testing -- Introduction to Molecular Typing -- The BeadChip System: A Flexible Array Format for Complex Nucleic Acid and Protein Analysis -- Implementation of HEA at Blood Centers: Prescreening, Rare Donors, Inventory Management -- Implementation of HEA BeadChip System at Medical Centers: Providing Extended Matched Units and Eliminating Complex Workups for Patients -- Human Platelet Antigen Genotyping and Diagnosis of Antiplatelet Alloimmunization -- Blood group genotyping by high-throughput DNA-analysis: Application to the Panel National de Référence du CNRGS -- Implementation and Assessment of High-Throughput Donor Typing at the Milan, Italy Immunohematology Reference Laboratory -- Implementation of the BioArray Erythrocyte Antigen (HEA) genotyping System BeadChip™ HEA: The Red Cross of Spain Experience -- Looking Beyond HEA: Matching SCD Patients for RH Variants Marion E Reid*, Christine Halter Hipsky -- Identification of Altered RHD and RHCE Alleles: A Comparison of Manual and Automated Molecular Methods -- Bayesian Classification Algorithms for Automated Allele Assignment. 
520 |a We have entered the era of molecular immunohematology in which DNA is analyzed to predict red blood cell and platelet phenotypes. Indeed, many laboratories and blood banks across the world have already adopted and implemented molecular techniques. Some fear that serology is now becoming outdated, but immunohematology techniques often supplement the work of serologists, and several leading serology laboratories are the very same ones that were early adopters of molecular immunohematology. This book is a thorough review of molecular immunohematology and is aimed at anyone interested in how it is changing blood bank and transfusion medicine. BeadChip Molecular Immunohematology opens with a history of serology before it provides an overview of gene expression, how genetic variations translate into antigenic differences on the surfaces of cells, and techniques that have been developed to detect genetic variations. It then describes in detail the BeadChip technology developed by BioArray Solutions, the molecular immunohematology system that has been most widely adopted in blood blank laboratories. The remainder of the book focuses on analyses and case studies from around the world to describe how molecular immunohematology is being used in various settings for various purposes. It includes a discussion of the significant advances that have been made to incorporate Rh testing on the BeadChip platform as well as the potential use of that system. 
650 0 |a Medicine. 
650 0 |a Immunology. 
650 0 |a Antibodies. 
650 0 |a Laboratory medicine. 
650 0 |a Molecular biology. 
650 0 |a Blood transfusion. 
650 1 4 |a Biomedicine. 
650 2 4 |a Biomedicine general. 
650 2 4 |a Immunology. 
650 2 4 |a Antibodies. 
650 2 4 |a Laboratory Medicine. 
650 2 4 |a Molecular Medicine. 
650 2 4 |a Blood Transfusion Medicine. 
700 1 |a Ness, Paul M.  |e editor. 
700 1 |a Sloan, Steve R.  |e editor. 
700 1 |a Moulds, JoAnn M.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781441975119 
856 4 0 |u http://dx.doi.org/10.1007/978-1-4419-7512-6  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)