Insertional Mutagenesis Strategies in Cancer Genetics

• Corporate Author: SpringerLink (Online service)
• Other Authors: Dupuy, Adam J. (Editor), Largaespada, David A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Subjects: Medicine.; Cancer research.; Human genetics.; Pharmacology.; Biomedicine.; Cancer Research.; Human Genetics.; Pharmacology/Toxicology.

Over the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observations sparked a series of experiments that even...