Insertional Mutagenesis Strategies in Cancer Genetics

• Corporate Author: SpringerLink (Online service)
• Other Authors: Dupuy, Adam J. (Editor), Largaespada, David A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Subjects: Medicine.; Cancer research.; Human genetics.; Pharmacology.; Biomedicine.; Cancer Research.; Human Genetics.; Pharmacology/Toxicology.

Over the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observations sparked a series of experiments that even...

Table of Contents:

• Chapter 1: Introduction: Author: Anton Berns (Netherlands Cancer Institute)
• Chapter 2: Retroviral mutagenesis in mouse leukemia/lymphoma: Author: David Largaespada, Ph.D. (University of Minnesota)
• Chapter 3: MMTV models of breast cancer: Author: John Hilkens (NKI)
• Chapter 4: Retroviral mutagenesis in other organisms: Author: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.)
• Chapter 5: Sleeping Beauty models of cancer: Author: Adam J. Dupuy, Ph.D. (University of Iowa)
• Chapter 6: Insertional mutagenesis in gene therapy patients: Author: David Williams, M.D. (Cincinnati Children’s Hospital)
• Chapter 7: Bioinformatics of high throughput insertional mutagenesis: Author: Keiko Akagi (NCI-Frederick).