Multistate GTPase Control Co-translational Protein Targeting

• Main Author: Zhang, Xin (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2012.
• Series: Springer Theses
• Subjects: Chemistry.; Analytical chemistry.; Bioorganic chemistry.; Biochemistry.; Proteomics.; Bioorganic Chemistry.; Analytical Chemistry.; Biochemistry, general.

Proteins act as macromolecular machinery that mediate many diverse biological processes - the molecular mechanisms of this machinery has fascinated biologists for decades. Analysis of the kinetic and thermodynamic features of these mechanisms could reveal unprecedented aspects of how the machinery f...

Table of Contents:

• Introduction
• A Multistep Mechanism for Assembly of the SRP-SR Complex
• Dynamics of the Transient Intermediate during SRP-SR Association
• Multiple Conformational Switches Control Cotranslational Protein Targeting
• Sequential Checkpoints Govern Substrate Selection during Cotranslational Protein Targeting.