Regulation of microRNAs

• Corporate Author: SpringerLink (Online service)
• Other Authors: Großhans, Helge (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer US, 2010.
• Series: Advances in Experimental Medicine and Biology, 700
• Subjects: Life sciences.; Human genetics.; Biochemistry.; Life Sciences.; Biochemistry, general.; Biomedicine general.; Human Genetics.

Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As...

Table of Contents:

• microRNA Biogenesis and Function
• Regulation of pri-miRNA Processing Through Smads
• Stimulation of pri-miR-18a Processing by hnRNP A1
• KSRP Promotes the Maturation of a Group of miRNA Precuresors
• Hormonal Repression of miRNA Biosynthesis Through a Nuclear Steroid Hormone Receptor
• Autoregulatory Mechanisms Controlling the Microprocessor
• Regulation of pre-miRNA Processing
• The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function
• miRNAs Need a Trim
• Properties of the Regulatory RNA-Binding Protein HuR and its Role in Controlling miRNA Repression
• Turnover of Mature miRNAs and siRNAs in Plants and Algae
• MicroRNases and the Regulated Degradation of Mature Animal miRNAs.