Targeting the Wnt Pathway in Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Goss, Kathleen H. (Editor), Kahn, Michael (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Oncology.; Medicine & Public Health.; Pharmacology/Toxicology.; Cancer Research.

The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathog...

Table of Contents:

• An Introduction to Wnt Signaling.- Regulation of Wnt Secretion and Distribution
• Wnt Signaling in Stem Cells
• Crosstalk of the Wnt Signaling Pathway
• Dysregulation of the WNT Pathway in Solid Tumors.- WNT/b-catenin Signaling in Leukemia
• Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
• Targeting Wnt Signalling in Cancer
• Inhibiting the Wnt Signaling Pathway with Small Molecules.- Targeting of Wnt Signaling Inside the Nucleus.-.