p53

• Κύριοι συγγραφείς: Ayed, Ayeda (Συγγραφέας), Hupp, Theodore (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US : Imprint: Springer, 2010.
• Σειρά: Molecular Biology Intelligence Unit, 1
• Θέματα: Medicine.; Cancer research.; Biomedicine.; Cancer Research.

Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene de...

Πίνακας περιεχομένων:

• TP53 Mutations in Human Cancers: Selection versus Mutagenesis
• Lessons on p53 from Mouse Models
• TP63, TP73: The Guardian’s Elder Brothers
• The Regulation of p53 Protein Function by Phosphorylation
• The p53-Mdm2 Loop: A Critical Juncture of Stress Response
• Cooperation between MDM2 and MDMX in the Regulation of p53
• Regulation and Function of the Original p53- Inducible p21 Gene
• p53 Localization
• Modes of p53 Interactions with DNA in the Chromatin Context
• p53’s Dilemma in Transcription: Analysis by Microarrays
• Tumor Viruses and p53
• p53 and Immunity.