Targeted Drug Strategies for Cancer and Inflammation

• Corporate Author: SpringerLink (Online service)
• Other Authors: Jackman, Ann L. (Editor), Leamon, Christopher P. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2011.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

The discoveries highlighted in this book parallel the emergence of innovative “molecular targeted” small molecules and monoclonal antibodies, i.e. agents that target proteins within highly activated signal transduction pathways that control proliferation.  Many of the tumor-targeted strategies descr...

Table of Contents:

• Biological Role, Properties and Therapeutic Applications of the Reduced Folate Carrier (RFC-SLC19A1) and the Proton-Coupled Folate Transporter (PCFT-SLC46A1)
• Folate Receptors and Therapeutic Applications
• Hormonal Control of Folate Receptor Genes
• Folate Receptor Targeted Radionuclide Imaging Agents
• Folate receptor targeted thymidylate synthase inhibitors
• Discovery of novel antifolate inhibitors of de novo purine nucleotide biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry
• Folate-receptor targeted cancer chemotherapy
• Anti-FR antibody generation and engineering: development of new therapeutic tools
• Folate Receptor Positive Macrophages: Cellular Targets for Imaging and Therapy of Inflammatory and Autoimmune Diseases
• Targeting Activated Macrophages via a Functional Folate Receptor for Potential Treatment of Autoimmune/Inflammatory Disorders.-.