New Agents for the Treatment of Acute Lymphoblastic Leukemia

• Corporate Author: SpringerLink (Online service)
• Other Authors: Saha, Vaskar (Editor), Kearns, Pamela (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2011.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

New Agents for the Treatment of Acute Lymphoblastic Leukaemia (ALL), examines the strategies for the use of new agents as well as possible targets of therapy in this disease. Though associated with high cure rates, relapsed disease has a poor outcome. Moreover, therapy is unduly prolonged and toxic....

Table of Contents:

• The need for new agents
• Identifying pre-clinical agents
• Pre-clinical evaluation
• Design of early phase trials
• Strategies for trial design and analyses
• Overview on Molecular and Animal models of ALL
• Apoptosis, BCL2
• Targeting Stem Cells
• Nucleoside Analogues
• Flt3 Inhibitors
• Tyrosine Kinase Inhibitors
• Monoclonal Antibodies
• Proteasome inhibitors
• Targeting epigenetic pathways in ALL.- Incorporating new therapies in frontline protocols.-.