Practical Preimplantation Genetic Diagnosis
Although treatment remains the major goal in the control of genetic disease, this is not yet a reality for most inherited conditions. In the absence of radical treatment, preimplantation genetic diagnosis (PGD) offers the answer to the control of these inherited conditions by predicting reproductive...
| Κύριος συγγραφέας: | |
|---|---|
| Συγγραφή απο Οργανισμό/Αρχή: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
London :
Springer London : Imprint: Springer,
2013.
|
| Έκδοση: | 2nd ed. 2013. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Primary prevention of genetic disorders and place of preimplantation diagnosis
- Approaches to preimplantation diagnosis
- Obtaining Biopsy Material
- Polar Body Diagnosis
- Pre-embryonic Genetic Diagnosis (PEGD)
- Preconception Testing for Paternally Derived Mutations by Sperm Duplication
- Development of artificial human gametes in vitro
- Embryo Biopsy
- Single cell genetic analysis
- DNA Analysis
- FISH Analysis
- Microarray analysis
- Preimplation diagnosis for single gene disorders
- Autosomal Recessive Diseases
- Autosomal Dominant Disorders
- X-linked disorders
- Homozygous or Double Heterozygous Recessive Conditions
- Conditions with No Available Direct Mutation Testing
- De Novo Mutations
- Late-onset disorders with genetic predisposition
- Inherited Predisposition to Cancer
- Alzheimer Disease
- Inherited Cardiac Diseases
- Blood Group Incompatibility
- Congenital Malformations
- Currarino Triad
- Dynamic Mutations
- Overall Experience of PGD for Mendelian Disorders
- PGD for HLA typing
- Fanconi Anemia
- World’s First PGD for HLA Typing
- Thalassemia
- Immunodeficiencies
- Preimplantation HLA Matching without PGD
- Limitations and future prospect of PGD for HLA Typing
- Practical Implications of PGD for HLA Typing
- Preimplantation diagnosis for chromosomal disorders
- First Polar Body Morphological Grading as Possible Potential Means for Preselecting Viable Oocytes
- Aneuploidy in human oocytes
- Testing for both meiosis I and meiosis II errors required for PGD of aneuploidies
- Inconsistency between Aneuploidy Types Predicted by PB1 and Detected by Cleavage Stage Testing
- Complex Errors and Aneuloidy Rescue in Female Meiosis
- Chromosome Specific Meiotic Error Origin and Its Impact on Embryo Viability
- Mitotic Errors in Cleaving Embryos in Relation to Meiosis Errors
- PCR-based aneuploidy testing in cleaving embryos
- Practical Relevance of Autosomal Monosomy Detection
- Uniparental Disomies
- Impact of PB Testing in Detection and Avoidance of Aneuploid Embryos for Transfer
- Chromosomal rearrangements
- Polar Boby Approach
- Blastomere Nuclear Conversion by Fusion with Mouse Oocytes
- Chemical Conversion Method
- Clinical outcome of preimplantation genetic diagnosis
- Safety of PGD
- Diagnostic Accuracy of PGD
- Reproductive outcome of PGD
- Controversy in Assessing Clinical Outcome of Preimplantation Aneuploidy Testing
- Reproductive Outcome Before and after PGD in Same Couples
- Possible Impact of Aneuploidy Origin
- Possible Impact of 24 Chromosome Aneuploidy Testing
- Preimplantation diagnosis and establishment of disease and individual specific human embryonic stem cell lines
- Sources for Establishing Human Embryonic Stem Cell Lines
- Human Embryonic Stem Cell Lines with Genetic Disorders
- Human Embryonic Stem Cell Lines with Chromosomal Disorders
- Genetic Disease Specific Human Embryonic Stem Cell Lines
- Development of individual specific hESC lines
- Human Embryonic Stem Cell Lines Resistant to HIV
- Progress in Study of Disease specific hESC Lines
- Social, ethical and legal aspects.
