Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development A Focus on Early Phase Clinical Studies /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Krentz, Andrew J. (Επιμελητής έκδοσης), Heinemann, Lutz (Επιμελητής έκδοσης), Hompesch, Marcus (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: London : Springer London : Imprint: Springer, 2015.
• Θέματα: Medicine.; Pharmacology.; Pharmaceutical technology.; Internal medicine.; Diabetes.; Metabolic diseases.; Medicine & Public Health.; Medicine/Public Health, general.; Internal Medicine.; Metabolic Diseases.; Pharmacology/Toxicology.; Pharmaceutical Sciences/Technology.

This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e...

Πίνακας περιεχομένων:

• 1. Review of physiology/pathophysiology
• 2. Methods for assessing insulin action in humans
• 3. Assessment of insulin secretion
• 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy
• 5. Isotopic tracers for the measurement of metabolic flux
• 6. Measuring food intake in clinical drug development
• 7. Measurement of energy expenditure
• 8. Assessment of body composition
• 9.  Assessment of cardiovascular safety of new diabetes drugs.