Physiological Assessment of Coronary Stenoses and the Microcirculation
Since the introduction of coronary angiography, a key technique in understanding coronary artery disease, a number of paradigms regarding its study and interpretation have taken place. Following an emphasis on improved angiographic and subsequent intracoronary imaging techniques, functional assessme...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
London :
Springer London : Imprint: Springer,
2017.
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| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- FOREWORD
- INTRODUCTION
- Part 1. The Coronary Circulation in Health and Disease
- STRUCTURE AND PHYSIOLOGY OF THE CORONARY CIRCULATION
- A historical perspective on coronary circulation
- The anatomy of epicardial ,coronary arteries and veins
- The structure of transmural vessels and coronary microcirculation
- Regulation of coronary blood flow
- Myocardial metabolism and blood supply
- Coronary capacitance and the myocardial pump model
- Extravascular compression and vascular waterfalls
- Extrinsic neural control of blood flow
- Hemodynamic effects of epicardial stenoses
- Modification of shear stress by stenoses
- Phasic characteristics in coronary blood flow
- PATHOLOGICAL CHANGES IN CORONARY CIRCULATION
- Epicardial coronary stenosis
- Microvascular remodelling
- Microvascular obstruction
- Extravascular compression of the microcirculation
- Endothelial dysfunction
- Collateral development
- EFFECT OF SPECIFIC PATHOLOGIES ON EPICARDIAL VESSELS AND THE MICROCIRCULATION
- Hypertension and left ventricular hypertrophy
- Diabetes
- Dyslipidemia
- Atherosclerosis. Acute coronary syndromes
- Atherosclerosis. Chronic ischemia
- Acute and chronic effects of percutaneous coronary interventions
- Valvular heart disease
- Part II. Invasive Assessment of the Coronary Circulation in the Catheterization Laboratory
- FRACTIONAL FLOW RESERVE (FFR)
- Understanding fractional flow reserve
- Current evidence on FFR as a clinical tool
- Application of fractional flow reserve to specific stenosis subsets
- INSTANTANEOUS WAVE FREE RATIO (iFR)
- Physiological principles of iFR
- Validation of iFR. Clinical registries
- Application of iFR in clinical scenarios
- CORONARY FLOW RESERVE
- Understanding coronary flow reserve
- Use of Doppler-tipped guidewires to calculate coronary flow reserve
- Relative and adjusted coronary flow reserve
- Use of the thermodilution principle to calculate coronary flow reserve
- INDICES OF CORONARY RESISTANCE
- Understanding indices of coronary resistance
- Stenosis resistance estimated from pressure-flow relationships
- Myocardial resistance estimated with thermodilution and pressure
- Microcirculatory resistance calculated from intracoronary pressure and Doppler
- Integration of pressure and flow indices of coronary stenosis severity
- WAVE INTENSITY ANALYSIS
- Understanding wave intensity analysis
- Wave patterns in coronary flow in health and disease
- Changes in WIA coronary patterns during trans-arterial valve implantation
- ASSESSMENT OF ENDOTHELIAL DYSFUNCTION
- Understanding endothelial modulation of vascular tone
- Assessment of endothelial dysfunction with acetylcholine challenge
- Other methods to assess endothelial dysfunction
- RESEARCH MODELS
- Relevant differences between coronary circulation in human and experimental animal models
- Computerised fluid dynamics applied to modelling of coronary circulation.
