Insulin-like Growth Factors and Cancer From Basic Biology to Therapeutics /

• Corporate Author: SpringerLink (Online service)
• Other Authors: LeRoith, Derek (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2012.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relati...

Table of Contents:

• Preface
• Epidemiology of IGF-1 and Cancer
• Aging and Cancer: The IGF-I Connection
• Obesity, Type 2 Diabetes and Cancer
• IGF System and Breast Cancer
• The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression
• Mouse Models of IGF-1 Deficiency
• Insulin-like Growth Factor Signaling in Pediatric Sarcomas
• Cancer Genes, Tumor Suppressors, and Regulation of IGF-1R Expression in Cancer
• Mouse Models of IGF-1R and Cancer
• Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy
• Targeting Insulin-like Growth Factor (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer
• Calories and Cancer:  The Role of Insulin-like Growth Factor
• Cancer Cell Metabolism
• Overlaps between the Insulin and IGF-1R and Cancer
• Index.