Natural Killer T cells Balancing the Regulation of Tumor Immunity /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Terabe, Masaki (Επιμελητής έκδοσης), Berzofsky, Jay A. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York, 2012.
• Έκδοση: 1.
• Σειρά: Cancer Drug Discovery and Development
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.  This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce la...

Πίνακας περιεχομένων:

• Preface.-  Introduction: Mechanisms of NKT cell-mediated adjuvant activity and function of iPS-derived NKT cells
• Structure and Recognition of Antigens for Invariant NKT Cells
• Invariant NKT cell-based vaccine strategies
• Immune regulation of tumor immunity by NKT cells
• The Regulation of CD1d+ and CD1d- tumors by NKT Cells
• DC-based immunotherapy targeting NKT cells
• Therapeutic Approaches Utilising NKT Cells
• NKT Cells of Cancer Patients & How Models can Inform Therapeutic Plans
• Understanding the role of Natural Killer T (NKT) cells in hematologic malignancies: progress and challenges
• Clinical trials with α-galactosylceramide (KRN7000) in advanced cancer
• Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer
• Index.  .