Endocrine FGFs and Klothos

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kuro-o, Makoto (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer US, 2012.
• Series: Advances in Experimental Medicine and Biology, 728
• Subjects: Life sciences.; Gene expression.; Cell biology.; Life Sciences.; Cell Biology.; Gene Expression.

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, c...

Table of Contents:

• The Structural Biology of the FGF19 Subfamily
• Klotho and bKlotho
• FGF23 and Syndromes of Abnormal Renal Phosphate Handling
• Evidence For FGF23 Involvement in a Bone‑Kidney Axis Regulating Bone Mineralization and Systemic Phosphate and Vitamin D Homeostasis
• FGF23, Klotho and Vitamin D Interactions: What Have We Learned from In Vivo Mouse Genetics Studies?
• FGF23 and the Parathyroid
• Regulation of Ion Channels by Secreted Klotho
• FGF23 in Chronic Kidney Disease
• Secreted Klotho and Chronic Kidney Disease
• FGF23 as a Novel Therapeutic Target
• Physiology of FGF15/19
• FGF19 and Cancer
• Understanding the Structure‑Function Relationship Between FGF19 and its Mitogenic and Metabolic Activities
• FGF21 as a Therapeutic Reagent.