Novel Developments in Stem Cell Mobilization Focus on CXCR4 /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Fruehauf, Stefan (Editor), Zeller, W. Jens (Editor), Calandra, Gary (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2012.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Recently, the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the way to the rational development...