Patho-Epigenetics of Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Minarovits, Janos (Editor), Niller, Hans Helmut (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2012.
• Subjects: Medicine.; Immunology.; Medical microbiology.; Virology.; Infectious diseases.; Biomedicine.; Medical Microbiology.; Medicine/Public Health, general.; Infectious Diseases.

In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensu...

Table of Contents:

• Epigenetic regulatory mechanisms
• Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome
• Dysfunction of the Methyl-Cpg Binding Protein Mecp2 in Rett Syndrome
• Epigenetic Alterations in Glioblastoma Multiforme
• Aberrant Epigenetic Regulation in Breast Cancer
• The Impact of Epigenetic Alterations on Diagnosis, Prediction and Therapy of Prostate Cancer
• Epigenetic Reprogramming in Lung Carcinomas
• Epigenetic changes in virus associated neoplasms
• Genetic and Epigenetic Determinants of Aggression
• Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder
• Disruption of Epigenetic Mechanisms in Autoimmune Syndromes
• Imprinting Disorders
• Epigenetics of cardiovascular diseases
• Microbe-induced epigenetic alterations.