p53 in the Clinics

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Hainaut, Pierre (Επιμελητής έκδοσης), Olivier, Magali (Επιμελητής έκδοσης), Wiman, Klas G. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on can...

Πίνακας περιεχομένων:

• Foreword
• p53 activities and the hallmarks of cancer
• The inheritance of p53
• p53: Guardian of the metabolome
• The p53 family and stem cell biology
• Mutant p53-driven tumorigenesis
• Humanized p53 mouse models
• p53 models for mammary carcinogenesis
• TP53 somatic mutations: Prognostic and predictive value in human cancers
• Assessing TP53 status in human tumors - lessons from breast cancer
• TP53 germline mutations: Genetics of Li-Fraumeni Syndrome
• TP53 gene therapy
• Upstream targets in the p53 pathway
• p53-reactivating molecules as research tools and anti-cancer drugs
• Restoring mutant p53 activity
• p53-immunotherapy of cancer
• Designing p53 trials: a surgical oncologist view
• p53 in the clinic: a pathologist view
• p53 in genetic counseling
• Index.