Experimental and Clinical Metastasis A Comprehensive Review /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Burnier, Julia V. (Επιμελητής έκδοσης), Burnier, Jr., Miguel N. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

The primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well...

Πίνακας περιεχομένων:

• Introduction
• Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth
• Introduction to Metastasis Suppressor Genes
• Metastasis suppressor genes
• Metastatic Dormancy & Metastatic Suppressor Genes
• Clinical Implications
• Growth Factor Systems and Cell Cycle Regulation
• Angiogenesis
• Inflammatory mediators in Tumorigenesis and Metastasis
• Role of stroma in disease progression
• Local spread
• Lymphatic – GI tract and Breast Cancer
• Hematogenous – Uveal Melanoma
• Other methods
• Haematogenous Models of Metastases
• Spontaneous, Induced, and Transgenic Models of Metastasis
• Orthotopic and Ectopic Models of Metastasis
• Animal Model Imaging Techniques
• Diagnosis of Metastasis
• Cancer Staging
• Diagnostic Immunohistochemistry in Tumor metastasis
• Genomics and Proteomics
• The role of chemotherapy for metastatic disease
• Integrating chemotherapy to surgery: Novel approaches in regionally aggressive cancer metastasis
• Palliative radiation therapy
• Role of Surgery in the Diagnosis and Management of Metastatic Cancer
• Prerequisite genetic traits for metastasis
• Metastasis Initiation
• Index.