Serotonin and Anxiety Neuroanatomical, Pharmacological, and Functional Aspects /

• Κύριος συγγραφέας: Maximino, Caio (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2012.
• Σειρά: SpringerBriefs in Neuroscience,
• Θέματα: Medicine.; Neurosciences.; Neurology.; Psychiatry.; Biomedicine.

Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medicat...

Πίνακας περιεχομένων:

• Introduction and scope of the review
• Anxiety and risk assessment
• Fear/panic and the fight/flight/freeze system
• “Coping” styles, stress reactivity, and the active-passive continuum
• Serotonin in the nervous system of vertebrates
• Synthesis and metabolism of serotonin
• Transport of serotonin: SERT and uptake
• Serotonin receptors
• 5-HT1A receptors
• 5-HT1B receptors
• 5-HT2C receptors
• Nodal structures in anxiety-like and panic-like responses
• Nodal structures regulating anxiety: The behavioral inhibition system
• “Limbic” portions of the medial prefrontal cortex
• The extended amygdala
• The ventral hippocampus
• The lateral habenula
• Nodal structures regulating panic: The cerebral aversive system
• The central amygdala
• The medial hypothalamic defense system
• The mesopontine rostromedial tegmental nucleus
• The periaqueductal gray area
• Locus coeruleus
• The dual role hypothesis
• Destruction or blockade of DRN neurons is anxiolytic and panicogenic
• The defensive context for increased serotonin release
• Topographic organization of DRN. - The dorsal portion of the DRN is part of a mesocorticolimbic system involved in anxiety-like responses
• The caudal portion of the DRN is highly responsive to stress-related peptides
• The lateral wings of the DRN are involved in panic-like responses
• General conclusions.