Biophysics for Therapeutic Protein Development

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Narhi, Linda O. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: Biophysics for the Life Sciences ; 4
• Θέματα: Medicine.; Pharmacology.; Medical biochemistry.; Proteins.; Biophysics.; Biological physics.; Biomedicine.; Pharmacology/Toxicology.; Medical Biochemistry.; Protein Science.; Protein-Ligand Interactions.; Biophysics and Biological Physics.

The last few decades have seen the genesis of protein therapeutics, such that these large molecule based drugs comprise an increasingly larger part of the commercial market. The conformation (overall global fold or three-dimensional structure) of these molecules is important for maintaining biologic...

Πίνακας περιεχομένων:

• Introduction
• High Throughput Biophysical Approaches to Therapeutic Protein Development
• Techniques for Higher Order Structure Determination
• Biophysical Techniques for Protein Size Distribution Analysis
• Qualification of biophysical methods for the analysis of protein therapeutics
• Application of Biophysics to the Early Developability Assessment of Therapeutic Candidates and its Application to Enhance Developability Properties
• Application of Biophysics in Formulation, Process and Product Characterization: Selected Case Studies
• Biophysical Analysis in Support of Development of Protein Pharmaceuticals
• Case Studies Applying Biophysical Techniques to Better Characterize Protein Aggregates and Particulates of Varying Size
• Investigation of Non Conformance During Protein Therapeutic Manufacturing
• Higher order structure and protein aggregate characterization of protein therapeutics: perspectives from good manufacturing practices and regulatory guidance
• Index.