Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary fu...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Thiriet, Marc (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
Σειρά:Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, 4
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 04322nam a22005775i 4500
001 978-1-4614-4370-4
003 DE-He213
005 20151125201027.0
007 cr nn 008mamaa
008 120928s2013 xxu| s |||| 0|eng d
020 |a 9781461443704  |9 978-1-4614-4370-4 
024 7 |a 10.1007/978-1-4614-4370-4  |2 doi 
040 |d GrThAP 
050 4 |a QH505 
072 7 |a PHVN  |2 bicssc 
072 7 |a PHVD  |2 bicssc 
072 7 |a SCI009000  |2 bisacsh 
082 0 4 |a 571.4  |2 23 
100 1 |a Thiriet, Marc.  |e author. 
245 1 0 |a Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems  |h [electronic resource] /  |c by Marc Thiriet. 
264 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2013. 
300 |a XV, 1064 p. 31 illus.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,  |x 2193-1682 ;  |v 4 
505 0 |a 1. Introduction -- 2. Signaling Lipids -- 3. Preamble to Cytoplasmic Protein Kinases -- 4. Cytoplasmic Protein Tyrosine Kinases -- 5. Cytoplasmic Protein Serine/Threonine Kinases -- 6. Dual-Specificity Protein Kinases -- 7. Mitogen-Activated Protein Kinase Module -- 8. Dual-Specificity Protein Kinases -- 9. Guanosine Triphosphatases and Their Regulators -- 10. Other Major Types of Signaling Mediators -- 11. Signaling Pathways -- 12. Conclusion -- References -- List of Currently Used Prefixes and Suffixes -- List of Aliases.-Complementary Lists of Notations -- Index. 
520 |a The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows. 
650 0 |a Physics. 
650 0 |a Cardiology. 
650 0 |a Systems biology. 
650 0 |a Biomathematics. 
650 0 |a Biophysics. 
650 0 |a Biological physics. 
650 0 |a Fluid mechanics. 
650 0 |a Biomedical engineering. 
650 1 4 |a Physics. 
650 2 4 |a Biophysics and Biological Physics. 
650 2 4 |a Biomedical Engineering. 
650 2 4 |a Mathematical and Computational Biology. 
650 2 4 |a Systems Biology. 
650 2 4 |a Engineering Fluid Dynamics. 
650 2 4 |a Cardiology. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781461443698 
830 0 |a Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,  |x 2193-1682 ;  |v 4 
856 4 0 |u http://dx.doi.org/10.1007/978-1-4614-4370-4  |z Full Text via HEAL-Link 
912 |a ZDB-2-PHA 
950 |a Physics and Astronomy (Springer-11651)