Natural Products and Cancer Drug Discovery

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Koehn, Frank E. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: Cancer Drug Discovery and Development
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Oncology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Natural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.  The historical record is strong, but what is the current impact of natural  products in the discovery and development of cancer drugs,...

Πίνακας περιεχομένων:

• Preface.-  The Impact of Natural Products upon Cancer Chemotherapy
• Identification and development of vascular disrupting agents: Natural products that interfere with tumor growth
• Discodermolide: Past, Present and Future
• HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents
• Natural Product Cytotoxins As Payloads For Antibody Drug Conjugates
• Natural Product Scaffolds in Cancer Therapy
• The Role of Genetic Engineering in Natural Product-based Anticancer Drug Discovery
• Accessing Anti-Cancer Natural Products by Plant Cell Culture
• Natural Products as Tools for Discovering New Cancer Targets
• Index.