Advances in Biology and Therapy of Multiple Myeloma Volume 1: Basic Science /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Munshi, Nikhil C. (Επιμελητής έκδοσης), Anderson, Kenneth C. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Despite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in...

Πίνακας περιεχομένων:

• Genomic strategies determining progressions from MGUS to Multiple Myeloma
• Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma
• Advances in MM gene expression profiling
• Growth factors in MM
• Role of Wnt signaling pathways in multiple myeloma pathogenesis
• mTOR pathway in multiple myeloma
• Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma
• Role of extracellular matrix in myeloma biology
• Osteoclasts: Potential target for blocking microenvironmental support of myeloma
• Targeting the BAFF/APRIL cytokine network in multiple myeloma
• Role of Osteoblast in myeloma pathology
• Migration and homing in Multiple Myeloma
• Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature
• Epigenetic regulation of myeloma within its bone marrow microenvironment
• Targeting mulitple myeloma tumor angiogenesis: focus on VEGF
• Novel in vivo model in myeloma
• Index.