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03062nam a22004815i 4500 |
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978-1-4614-4741-2 |
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DE-He213 |
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20151029231716.0 |
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cr nn 008mamaa |
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121206s2013 xxu| s |||| 0|eng d |
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|a 9781461447412
|9 978-1-4614-4741-2
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|a 10.1007/978-1-4614-4741-2
|2 doi
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|a RC261-271
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|a MJCL
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|a MED062000
|2 bisacsh
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|a 614.5999
|2 23
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|a Advances in DNA Repair in Cancer Therapy
|h [electronic resource] /
|c edited by Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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| 300 |
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|a VIII, 312 p.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Cancer Drug Discovery and Development ;
|v 72
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|a Preface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index.
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|a This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
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| 650 |
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|a Medicine.
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| 650 |
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|a Cancer research.
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| 650 |
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|a Molecular biology.
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| 650 |
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4 |
|a Biomedicine.
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| 650 |
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4 |
|a Cancer Research.
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| 650 |
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4 |
|a Molecular Medicine.
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| 700 |
1 |
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|a Panasci, Lawrence.
|e editor.
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| 700 |
1 |
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|a Aloyz, Raquel.
|e editor.
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| 700 |
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|a Alaoui-Jamali, Moulay.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9781461447405
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| 830 |
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|a Cancer Drug Discovery and Development ;
|v 72
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-1-4614-4741-2
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SME
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| 950 |
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|a Medicine (Springer-11650)
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