Advances in DNA Repair in Cancer Therapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Panasci, Lawrence (Επιμελητής έκδοσης), Aloyz, Raquel (Επιμελητής έκδοσης), Alaoui-Jamali, Moulay (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: Cancer Drug Discovery and Development ; 72
• Θέματα: Medicine.; Cancer research.; Molecular biology.; Biomedicine.; Cancer Research.; Molecular Medicine.

This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin.  The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombination...

Πίνακας περιεχομένων:

• Preface
• Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs
• DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy?
• Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses
• The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy
• Important Roles of ERCC1 in DNA Repair and Targeted Therapy
• The role of BRCA1 and BRCA2 in anticancer drug therapy
• DNA-PK in CLL Chemotherapy
• Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair
• Cellular protection against the antitumor drug bleomycin
• ATR as a Therapeutic Target
• Telomeres, Telomerase and DNA Damage Response in Cancer Therapy
• RAD51 is a key protein of DNA repair and homologous recombination in humans
• Index.