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03370nam a22004575i 4500 |
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978-1-4614-4815-0 |
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20150519180919.0 |
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120913s2013 xxu| s |||| 0|eng d |
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|a 9781461448150
|9 978-1-4614-4815-0
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|a 10.1007/978-1-4614-4815-0
|2 doi
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|a Microdialysis in Drug Development
|h [electronic resource] /
|c edited by Markus Müller.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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|a XII, 340 p.
|b online resource.
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|a text
|b txt
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|a computer
|b c
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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|a AAPS Advances in the Pharmaceutical Sciences Series,
|x 2210-7371 ;
|v 4
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|a Introduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques – Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.
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|a In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
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|a Medicine.
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| 650 |
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|a Pharmaceutical technology.
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|a Biomedicine.
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| 650 |
2 |
4 |
|a Pharmaceutical Sciences/Technology.
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| 650 |
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|a Biomedicine general.
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| 700 |
1 |
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|a Müller, Markus.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9781461448143
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| 830 |
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|a AAPS Advances in the Pharmaceutical Sciences Series,
|x 2210-7371 ;
|v 4
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-1-4614-4815-0
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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