Systems Biology of Tuberculosis

• Corporate Author: SpringerLink (Online service)
• Other Authors: McFadden, Johnjoe (Editor), Beste, Dany J.V (Editor), Kierzek, Andrzej M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Life sciences.; Medical microbiology.; Systems biology.; Microbiology.; Life Sciences.; Systems Biology.; Medical Microbiology.

Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis....

Table of Contents:

• Foreword
• Modeling Mycobacterium tuberculosis H37Rv in silico
• Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis
• Probing Gene Regulatory Networks to Decipher Host-Pathogen Interactions
• Metabolism of Mycobacterium tuberculosis
• Protein-protein interaction in the –omics era: Understanding Mycobacterium tuberculosis function
• A systems biology approach for understanding granuloma formation and function in tuberculosis
• Stochastic gene expression in bacterial pathogens: a mechanism for persistence?
• Drug Discovery
• Diagnosis
• Index.