Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Singh, Manmohan (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US : Imprint: Springer, 2013.
• Θέματα: Medicine.; Immunology.; Medical microbiology.; Vaccines.; Pharmaceutical technology.; Biomedicine.; Medical Microbiology.; Vaccine.; Pharmaceutical Sciences/Technology.

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and f...

Πίνακας περιεχομένων:

• Critical parameters that govern the optimization of vaccine formulations
• Development of Biophysical assays to better understand vaccine formulation stability
• Rational design of vaccine formulations
• Monitoring stability and efficacy of multi-valent vaccine formulations.-  Overcoming challenges of multi component alum formulations.-  Delivery of various TLR adjuvants using alum platform
• History of use of emulsions for vaccine delivery
• MF59 o/w emulsion : History and safety over the last 2 decades
• Optimizing novel nanoemulsions for delivery of next generation antigens and adjuvants
• Modulating vaccine responses with innate immunity : Use of PLGA nanoparticles for delivering multiple TLR agonists
• Shape matters : Role of nanoparticle shape in induction of immune responses to a vaccine.        .