Tandem Repeat Polymorphisms Genetic Plasticity, Neural Diversity and Disease /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Hannan, Anthony J. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2012.
• Σειρά: Advances in Experimental Medicine and Biology,
• Θέματα: Medicine.; Medical genetics.; Neurosciences.; Biomedicine.; Biomedicine general.; Gene Function.

This book addresses the role of tandem repeat polymorphisms (TRPs) in genetic plasticity, evolution, development, biological processes, neural diversity, brain function, dysfunction and disease. There are hundreds of thousands of unique tandem repeats in the human genome and their polymorphic distri...

Πίνακας περιεχομένων:

• Tandem Repeat Polymorphisms: Mediators of Genetic Plasticity, Modulators of Biological Diversity and Dynamic Sources of Disease Susceptibility
• Evolution of Simple Sequence Repeats as Mutable Sites
• Single Amino Acid and Trinucleotide Repeats: Function and Evolution
• Promoter Microsatellites as Modulators of Human Gene Expression
• Dynamic Mutations: Where Are They Now
• Unstable Mutations in the FMR1 Gene and the Phenotypes
• Molecular Pathways to Polyglutamine Aggregation
• Polyglutamine Aggregation in Huntington and Related Diseases
• Selective Neurodegeneration, Neuropathology and Symptom Profiles in Huntington’s Disease
• Kennedy’s Disease: Clinical Significance of Tandem Repeat s in the Androgen Receptor
• Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia: A Systematic Review
• Polyalanine Tract Disorders and Neurocognitive Phenotypes.