Sequential Experimentation in Clinical Trials Design and Analysis /

• Κύριοι συγγραφείς: Bartroff, Jay (Συγγραφέας), Lai, Tze Leung (Συγγραφέας), Shih, Mei-Chiung (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: Springer Series in Statistics, 298
• Θέματα: Statistics.; Statistics for Life Sciences, Medicine, Health Sciences.; Statistics, general.; Statistical Theory and Methods.

This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequenti...

Πίνακας περιεχομένων:

• Introduction
• Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
• Sequential Testing Theory and Stochastic Optimization over Time
• Group Sequential Design of Phase II and III Trials
• Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
• Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
• Confidence Intervals and p-Values
• Adaptive Design of Confirmatory Trials
• References.