E-Cell System Basic Concepts and Applications /

• Main Authors: Arjunan, Satya Nanda Vel (Author), Dhar, Pawan K. (Author), Tomita, Masaru (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: Molecular Biology Intelligence Unit,
• Subjects: Medicine.; Molecular biology.; Biomedicine.; Molecular Medicine.; Biomedicine general.

The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulatio...

Table of Contents:

• Introduction to Whole Cell Modeling
• Foundations of E‑Cell Simulation Environment Architecture
• Distributed Cell Biology Simulations with the E‑Cell System
• A Guide to Modeling Reaction‑Diffusion of Molecules with the E‑Cell System
• A Model Library of Bacterial Chemotaxis on E‑Cell System
• Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes
• Simulation of Human Erythrocyte Metabolism
• Dynamic Kinetic Modeling of Mitochondrial Energy Metabolism
• A Computational Model of the Hepatic Lobule
• Decoding the Signaling Mechanism of Toll‑Like Receptor 4 Pathways in Wild Type and Knockouts
• Modeling of Hsp70‑Mediated Protein Refolding.