Androgen-Responsive Genes in Prostate Cancer Regulation, Function and Clinical Applications /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Wang, Zhou (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Human genetics.; Gene therapy.; Biomedicine.; Cancer Research.; Gene Therapy.; Human Genetics.

Recent studies demonstrated a key role of the androgen receptor in the development of castration-recurrent or -resistant prostate cancer (CRPC), which is deadly and in urgent need of more effective therapies.  Understanding the functions of androgen-responsive genes and their regulation and deregula...

Πίνακας περιεχομένων:

• Preface
• Roles of androgen receptor coregulators and cell signaling in regulation of androgen-responsive genes
• Selective and classical Androgen Response Elements in androgen-regulated gene expression
• Negative androgen-response elements in androgen target genes
• Chromatin looping and long distance regulation by androgen receptor
• The Functionality of Prostate Cancer Predisposition Risk Regions is revealed by AR Enhancers
• Mechanisms of ARE-independent Gene Activation by the Androgen Receptor in Prostate Cancer Cells: potential targets for better intervention strategies
• Androgen action, Wnt signaling, and prostate tumorigenesis
• Toward Revealing the Complexity of Androgen Responsive Protein and Non-coding Transcripts in Prostate Cancer
• Androgen-Responsive Gene Expression in Prostate Cancer Progression
• Androgen receptor regulated genes in prostate cancer initiation vs metastasis
• Androgen-Independent Induction of Androgen-Responsive Genes By Interleukin-6 Regulation
• The effect of AR overexpression on androgen signaling in prostate cancer
• The expression signature of androgen receptor splice variants and their distinctive transcriptional activities in castration-resistant prostate cancer
• Androgen regulation of the cell cycle in prostate cancer
• Androgen Receptor Signaling Interactions Control Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer Progression
• Androgen receptor regulation of serum response factor signaling in prostate cancer
• Regulation of angiogenesis by androgen-responsive gene EAF2
• The role of miR-21, an androgen-regulated microRNA, in prostate cancer
• Androgen dependent oncogenic activation of ETS transcription factors by recurrent gene fusions in prostate cancer: Biological and Clinical Implications
• Clusterin as a target for treatment of castration-resistant prostate cancer
• Index.