The Hippo Signaling Pathway and Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Oren, Moshe (Επιμελητής έκδοσης), Aylon, Yael (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Medical microbiology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Medical Microbiology.; Biomedicine general.

The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just...

Πίνακας περιεχομένων:

• Introduction
• Merlin and Angiomotin in Hippo-Yap signaling
• MST1/2 and other upstream signaling that affect Hippo pathway function
• YAP1 uses its modular protein domains and conserved sequence motifs to orchestrate diverse repertoires of signaling
• Regulation of YAP and TAZ transcription co-activators
• Regulation of YAP and TAZ by epithelial plasticity
• Hippo pathway and apoptosis
• YAP and p73: a matter of mutual specificity in tumour suppression
• The c-Abl/YAP/p73 apoptotic module and the Hippo pathway
• Hippo in cell cycle and mitosis
• Hippo and mouse models for cancer
• Roles of Hippo signaling during mouse embryogenesis
• Hippo Signaling and stem cells
• Hippo signaling and organ size control
• Hippo signaling in heart development
• Cell competition and the Hippo pathway
• Non-canonical roles from the Hippo pathway
• Index.