Stress-Induced Mutagenesis

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Mittelman, David (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Human genetics.; Biochemistry.; Biomedicine.; Human Genetics.; Biochemistry, general.; Biomedicine general.

The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In “Stress-Induced Mutagenesis”, leading experts provide the key evidence for and the molecular details of stress-induced genetic...

Πίνακας περιεχομένων:

• Preface
• Stress-induced mutagenesis in bacteria
• Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress
• Transcription-mediated mutagenic processes
• Transposon mutagenesis in disease, drug discovery and bacterial evolution
• Hsp90 as a capacitor of both genetic and epigenetic changes in the genome during cancer progression and evolution
• Inheritance of stress-induced epigenetic changes mediated by the ATF-2 family of transcription factors
• Microsatellite Repeats: Canaries in the Coalmine
• Genetic instability Induced by hypoxic stress
• Radiation-induced delayed genome Instability and hypermutation in mammalian cells
• Radiation-induced bystander effects and stress-induced mutagenesis
• Stress induced mutagenesis, genetic diversification, and cell survival via anastasis, the reversal of late stage apoptosis
• The transgenerational effects of parental exposure to mutagens in mammals
• Revisiting mutagenesis in the age of high-throughput sequencing
• Index.