MHC Class I Antigens In Malignant Cells Immune Escape And Response To Immunotherapy /

• Main Authors: Aptsiauri, Natalia (Author), Garcia-Lora, Angel Miguel (Author), Cabrera, Teresa (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Series: SpringerBriefs in Cancer Research ; 6
• Subjects: Medicine.; Cancer research.; Immunology.; Molecular biology.; Biomedicine.; Cancer Research.; Molecular Medicine.

Abnormal expression of MHC class I molecules in malignant cells is a frequent occurrence that ranges from total loss of all class I antigens to partial loss of MHC specific haplotypes or alleles. Different mechanisms are described to be responsible for these alterations, requiring different therapeu...

Table of Contents:

• Overview of MHC Class I Antigens
• HLA Class I Expression In Human Cancer
• MHC Class I Expression In Experimental Mouse Models Of Cancer: Immunotherapy Of Tumors With Different MHC-I Expression Patterns
• Potential Therapeutic Approaches For Increasing Tumor Immunogenicity By Upregulation Of Tumor HLA Class I Expression
• Conclusion.