Molecular and Cellular Mechanisms of Antibody Activity

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Nimmerjahn, Falk (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Immunology.; Medical microbiology.; Virology.; Biomedicine.; Medical Microbiology.

This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of mol...

Πίνακας περιεχομένων:

• IgM and IgD in infection and inflammatory diseases
• Immunoglobulin A – molecular mechanisms of function and role in immune defense
• Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors
• The role of IgG in immune responses
• Molecular and cellular pathways involved in the anti-inflammatory activity of IgG
• Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins
• Cross-talk between antibodies, IgG Fc receptors and the complement system
• Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn
• Antibody mediated regulation of humoral immunity
• Engineered antibody derivatives in preclinical and clinical development.