Molecular and Cellular Mechanisms of Antibody Activity

• Corporate Author: SpringerLink (Online service)
• Other Authors: Nimmerjahn, Falk (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2013.
• Subjects: Medicine.; Immunology.; Medical microbiology.; Virology.; Biomedicine.; Medical Microbiology.

This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of mol...

Table of Contents:

• IgM and IgD in infection and inflammatory diseases
• Immunoglobulin A – molecular mechanisms of function and role in immune defense
• Crystal structures of human IgG Fc-fragments and their complexes with Fc Receptors
• The role of IgG in immune responses
• Molecular and cellular pathways involved in the anti-inflammatory activity of IgG
• Example of the Pathogenic Potential of Two Sets of Autoantibodies: Anti-RBC and IgG3 RF Cryoglobulins
• Cross-talk between antibodies, IgG Fc receptors and the complement system
• Regulation of immunological responses by the neonatal Fc receptor for IgG, FcRn
• Antibody mediated regulation of humoral immunity
• Engineered antibody derivatives in preclinical and clinical development.