Resistance to Immunotherapeutic Antibodies in Cancer Strategies to Overcome Resistance /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Bonavida, Benjamin (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: Resistance to Targeted Anti-Cancer Therapeutics, 2
• Θέματα: Medicine.; Cancer research.; Immunology.; Antibodies.; Molecular biology.; Biomedicine.; Cancer Research.; Molecular Medicine.

The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb...

Πίνακας περιεχομένων:

• Preface
• Introduction and generation of chimeric and humanized mAbs
• mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment
• Antibodies directed against different major cancers: Effects when used  alone or in combination with drugs
• Mechanisms of antibodies-mediated responses, in vitro and in vivo
• Molecular Pathways
• Molecular Signatures
• Identification of resistance targets for intervention
• Various chemicals that can sensitize resistant tumor cells
• Other mAbs
• Proteasome inhibitors
• Divalent mAbs
• Antibodies coupled to chemical inhibitors
• Antibodies coupled to cytokines
• Nanoparticles with mAbs
• Index.